Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors

Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) N-hydroxy-2-propylpentanamide (HL2), have been prepared using FTIR, 1H, 13C, 119Sn NMR spectroscopy. Particular emphasis was put on binding characteristics ligands. The structures were additionally analyzed Density functional theory at B3LYP-D3BJ/6-311++G(d,p)(H,C,N,O)/LanL2DZ(Sn) level. theoretical IR spectra compared to spectroscopic data, it concluded that predicted described well experimental ones. stability different isomers HL1 HL2 assessed Natural Bond Orbital analysis, importance intramolecular hydrogen bond outlined. interactions between donor atoms Sn investigated correlated changes in chemical shift wavenumbers characteristic vibrations.